According to a March 2023 extract of the Florida Plant Rescue Database, Fairchild Tropical Botanic Garden holds 1 accessions of Chamaesyce deltoidea ssp. serpyllum totalling approximately 48 seeds representing 14 maternal lines.
Florida endemic, known only from Big Pine Key in Monroe County. Few occurrences, but some large populations. Very narrow range. Occurs on the edges of hammocks and pinelands. Given its narrow habitat range, and the small number of individuals that occur, Chamaesyce deltoidea ssp. serpyllum is vulnerable to extinction, and is furthermore threatened by development pressure on habitat, suppression and disruption of natural fire regimes, and non-native plant invasions.
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