According to a March 2023 extract of the Florida Plant Rescue Database, Bok Tower Gardens holds 1 accessions of Matelea floridana totalling approximately 75 seeds.
Known from approx. 20 occurrences in central and northern peninsular Florida and from a few reports from the Florida panhandle and adjacent southwestern Georgia (only one locality known in Georgia). The species' habitat is threatened by development, successional pressure, and exotic plants. Fire may be needed to maintain the forest canopy gaps in which it thrives, but clearcutting would probably lead to its disappearance.
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